Abstract
Summary
Methimazole, an antithyroid drug, and thiambutosine, an antimicrobial active against M. leprae in the mouse, were both found to inhibit multiplication of M. leprae in the mouse foot pad when administered in concentrations too small to inhibit thyroid function of the mice. Moreover, methimazole inhibited multiplication in vitro of a number of cultivable Mycobacteria. Although the antimicrobial and the antithyroid effects may be exerted through a common mechanism, it appears that methimazole nevertheless possesses direct antimicrobial properties.
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