Abstract
Summary
The induction of aggregation of platelets obtained from hypothyroid rats was investigated. Using adenosine diphosphate, collagen and endotoxin as aggregating agents, a uniform depression of aggregability was noted. Since hypothyroid rats do not have concomitant changes in lipid metabolism, the hypoaggregability of platelets in hypothyroidism is directly related to the disturbed endocrine function and can be demonstrated in the absence of changes in lipid metabolism.
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