Abstract
Summary
The effect of exogenous ATP treatment (10 μmoles iv) on glucoregulation was evaluated in male Holtzman rats. ATP treatment decreased lethality of insulin in doses of 1 and 2 U sc, blunted the hypoglycemic response to 0.05, 0.10 and 0.20 U insulin sc, increased the iv glucose disappearance rate, depressed the in vivo oxidation of 400 mg glucose, and inhibited the insulin response of epididymal fat pads to insulin in vitro. The data are consistent with the Chang-Cuatrecasas hypothesis that exogenous ATP inhibits insulin-mediated effects on glucose metabolism via phosphorylation of a membrane component.
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