Abstract
Summary
This study examined whether or not secretin inhibited pentagastrin stimulated growth of colonic mucosa in rats. Pentagastrin (250 μg/kg) caused an approximate doubling of mucosal DNA synthesis which was completely prevented by secretin in doses of 37.5 and 75 U/kg. The effect of secretin was dose dependent and occurred with as little as 9 U/kg. Secretin had no effect on either DNA synthesis or content when administered by itself. The dose of 75 U secretin per kg also completely prevented a 60% increase in DNA content stimulated by pentagastrin.
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