The Effect of Somatostatin on Glucose Stimulated Adenosine 3′-5,Monophosphate Accumulation and Glucose Oxidation by Isolated Rat Islets of Langerhans 1 3

Abstract

Summary

Somatostatin at a final concentration of 1 μg or 10 μg/ml did not affect glucose stimulated oxidation of either D-[¹⁴C]₁ or D-[¹⁴C]₆ glucose, but inhibited both insulin release and cyclic AMP accumulation by isolated rat islets of Langerhans.