Abstract
Summary
Both at 1 and at 24 hr, 51641 inhibited serotonin oxidation to a greater extent than phenylethylamine oxidation in brain, heart and liver when it was injected at different dose levels into rats. After a 30 mg/kg dose, 51641 produced a long-lasting inhibition of serotonin oxidation in all three tissues (half-life 3-6 days). In contrast, the initial half-life of inhibition of phenylethylamine oxidation was only 0.3-0.4 days in brain and liver (4 days in heart). Apparently 51641 does not inhibit type B MAO irreversibly in vivo.
Get full access to this article
View all access options for this article.