Abstract
Summary
In Dahl hypertension-resistant (R) and hypertension-sensitive (S) lines of rats, an ip cadmium injection exacerbated two-kidney Goldblatt hypertension and mortality in S but not in R rats. Renal and hepatic cadmium concentrations of S rats were markedly higher than those of R rats. These observations imply that the genetic background critically affects the adverse effects of cadmium on two-kidney Goldblatt hypertension in Dahl rats.
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