Abstract
Summary
Combination of noncholestatic doses of manganese and bilirubin produced a dramatic fall in bile flow. Furthermore the order and injection times were critical, suggesting that the manganese-bilirubin interaction is complex and proceeds via a shortlived intermediate pathway. Protection against cholestasis seems assured by BSP before its conjugation. Because the protection is abolished either by increasing the bilirubin dosage or lowering the BSP dosage a BSP-bilirubin interaction appears to be a possible mechanism for the protection seen in manganese-bilirubin cholestasis.
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