Abstract
Summary
The net changes in collagen mass and collagen concentration of kidneys, measured by hydroxyproline, were determined after unilateral nephrectomy in 12-week-old Lewis rats. Observations were done 10 to 120 days after nephrectomy. Compensatory growth shows a distinct increase in collagen mass of the remaining kidney. By 120 days, the renal dry weight in the hypertrophic kidney increased to 160% of the control. At that time, the collagen mass per whole kidney increased to 156%. While the increase in dry weight is almost completed by 20 days, the collagen mass continued to increase during the 120 days of the study.
Get full access to this article
View all access options for this article.