Further Enhancement by Tryptophan of Hepatic Protein Synthesis Stimulated by Phenobarbital or Cortisone Acetate 1 2

Abstract

Summary

This study was concerned with the effect of the administration of tryptophan on hepatic polyribosomes and protein synthesis in rats in which hepatic protein synthesis was already enhanced by the administration of phenobarbital or cortisone acetate. Previously it has been demonstrated that tryptophan has a stimulatory effect on hepatic protein synthesis of fasted or hepatotoxin-treated animals. The present study revealed that tryptophan administration to rats that have had hepatic protein synthesis enhanced by treatment with phenobarbital (1–3 days) or cortisone acetate (14 hr) further stimulated hepatic polyribosomes toward heavier aggregation and hepatic protein synthesis (in vitro).