Abstract
Summary
Intraperitoneal injections of 1–5 I.U. of renin purified extracts, obtained either from hog or rat kidneys, in hyperhydrated rats receiving distilled water or 0.4% NaCl (5% body weight) produce not only a striking increase in the sodium excretion rate but a very significant decrease in kallikrein excretion as well. In the urine excreted in the first hour after renin administration kallikrein practically disappeared in the urine; with higher doses the inhibitory effect was very marked and lasted up to 120 minutes. In the same rats under a second hyperhydration, nonassociated with renin injection, kallikrein tends to return to control levels.
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