Abstract
Summary
The beta-adrenergic blocking potency and myocardial depressant properties of seven β-adrenergic blocking agents were compared in unanesthetized atherosclerotic rabbits. The order of potency with regard to blockade of heart-rate responses to isoproterenol (0.4 μg/kg) was pindolol > nadolol > timolol > atenolol > oxprenolol > alprenolol > propranolol. Pindolol, oxprenolol and alprenolol caused the greatest depression of left ventricular dP/dt followed by propranolol, atenolol, timolol and nadolol. The “myocardial safety index” (MD50/ID50) was greatest for nadolol followed by timolol, atenolol, pindolol, propranolol, oxprenolol and alprenolol.
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