Evidence for Uptake of Nonceruloplasminic Copper in the Brain: Effect of Ionic Copper and Amino Acids

Abstract

Summary

The initial net uptake of Cu(II) into the brain was studied in rats using the single microcirculatory pass technique of Oldendorf. The results indicate that the net influx of Cu(II) is facilitated by a nonsaturable process over a wide range of concentrations. Several amino acids enhance the uptake or early retention of Cu(II). However, the amino acids which promote Cu uptake in brain appear to be different from those previously shown to be effective in other cell systems in vitro.