Cationic Conductances of Nutrient and Secretory Membranes of Frog Stomach in Cl - - free Solutions

Abstract

Summary

The K⁺ conductance in Cl^- -free media of the frog gastric mucosa of Rana pipiens was found to be relatively high and essentially the same for both the nutrient and secretory membranes. The replacement of Na⁺ with either Mg²⁺ or Ca²⁺ in either the nutrient or secretory solution and in the presence of 4 mM K⁺ in both solutions increased the resistance and decreased the PD. An analysis of the results for the nutrient membrane suggests that Mg²⁺ and Ca²⁺ block the K⁺ pathway.