Cell Proliferation of Canine Cyclic Hematopoietic Marrow in Diffusion Chambers

Abstract

Summary

The ability (Cytopoietic Potential) of marrow from dogs with cyclic hematopoiesis to proliferate within diffusion chambers that had been implanted into irradiated mice has been studied. Cytopoietic Potentials fluctuated over the hematopoietic cycle from near normal levels during the period of peripheral neutropenia to significantly below normal when peripheral blood neutrophils were elevated. Although interpretation of the results has to be tempered by the lack of knowledge concerning the nature of the cell responsible for cell generation in diffusion chambers, the data appear to suggest a compromised multipotential stem cell compartment in cyclic hematopoiesis. Periodic proliferation of these stem cells may account for the previously recognized in phase cycling of committed granulocytic and erythrocytic progenitor cells.