Abstract
Summary
Stimulated human monocytes produce two physically distinct pyrogens. Both of these partially purified pyrogens will lower plasma iron and zinc and increase blood neutrophils when injected into rats or rabbits. When equivalent pyrogenic doses were injected, the two pyrogens gave quantitatively similar leukocytic endogenous mediator activities (i.e., granulocytosis and lowering of plasma iron and zinc). These results, therefore, provide evidence that leukocytic endogenous mediator can be produced by monocytes as well as by granulocytes.
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