Abstract
Summary
Shope papillomas neonatally induced in domestic rabbits were observed to convert into squamous cell carcinomas after the lapse of a year or more. The ulceration of the tumor, the bluish coloration of the serum and the elevation of serum copper level were concomitantly observed in these animals. The serum copper was found to be augmented two to six times higher among animals with malignancies than those with benign papillomas. Disc electrophoretic analysis of the serum showed that ceruloplasmin activity was manifested as single and double bands, before and after the malignant conversion, respectively. The serum at parturition also showed an elevated serum copper level but only a single band of ceruloplasmin appeared in disc electrophoretic analysis.
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