Abstract
Summary
The nature of attachment of hepatic ribosomes to membranes after spar-somycin treatment in vivo of rats and mice was investigated. The results based upon the influence of treatment in vitro with different concentrations of KC1 and with puromycin on the detachment of membrane-bound ribosomes from membranes of livers of spar-somycin-treated animals revealed that these ribosomes are attached to membranes by peptides as well as by ionic bridging and are considered as fall-off ribosomes. Similar effects have been described after treatment in vivo with dimethylnitrosamine. In contrast, treatment in vivo with ethionine or CCL produced run-off ribosomes which are attached only by ionic bridging since they become detached in vitro with KC1 treatment alone.
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