Abstract
Summary
The putative role of dietary fiber was investigated in dimethylhydrazine (DMH)-induced colon carcinogenesis in rats. Four groups of 10 male Sprague-Dawley rats each were used: Group I-Control; Group 11-30 mg/kg DMH; Group III-20% bran; and Group IV-Bran and DMH. Intestinal transit times were decreased and fecal outputs were increased in rats given the 20% bran diet. In Group 11, all 10 rats had tumors with a mean of 6.4 tumors/rat whereas in Group IV, 6 of 9 rats (67%) had tumors with a mean of only 1.8 tumors/rat/group and 2.7 tumors/rat which had tumors. The size and distribution of these tumors were similar in both groups. Bran in the diet had little effect on the incidence, number, and distribution of duodenal tumors.
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