Abstract
Summary
The formation of splenic antibody-forming cells was determined by the Jerne agar-plaque technique in normal rats and in rats deficient in thiamin, riboflavin, biotin or folic acid immunized with sheep erythrocytes. The number of antibody-forming cells was reduced in all deficiency states with thiamin deficiency having the least effect. This decreased cellular immune response in biotin and folic acid deficiencies was partially restored to normal by administration of biotin or folic acid, respectively, shortly before immunization.
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