Abstract
Summary
Immunologic impairment occurs in mice bearing mastocytoma tumors or injected with cell free extracts and/or ascites fluids from the tumor bearing animals. In the present study it was found that the 19S IgM antibody response to sheep red blood cells as assessed at the individual hemolytic plaque forming cell level was preferentially affected. Whereas there were 60-80% fewer IgM PFCs in mice given a primary injection with sheep erythrocytes, there was only a slight effect on appearance of indirect 7S IgG plaque forming cells. Furthermore, mice primed with sheep red blood cells and then implanted with mastocytoma cells showed a marked impairment of the secondary IgM response but no depression of the IgG response. Injection of cell free ascites fluid derived from mastocytoma-bearing mice into normal recipient mice before primary or secondary immunization with sheep red cells resulted in marked depression only of the IgM response. These results indicate that mastocytoma affects preferentially in immunocytes producing IgM hemolytic antibody and not those involved in formation of 7S antibody.
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