Abstract
Summary
Both theophylline, a phospho-diesterase inhibitor, and ethacrynic acid, a Na+-K+-ATPase inhibitor, produced similar increases in BSIF in the rat. Whereas theophylline significantly decreased BSDF, ethacrynic acid increased BSDF. These results suggest that the mechanism responsible for generation of both BSIF and BSDF are multifactorial and further study will be necessary to define them.
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