Abstract
Summary
Progesterone and estradiol were measured in blood and blastokinin was assayed in uterine flushings collected from rabbits prior to and during treatment with melengestrol acetate (MGA) or corn oil and during the subsequent period of induced pseudopregnancy. Blastokinin was elevated during MGA treatment, but was transiently suppressed on Day 3 of pseudo-pregnancy after MGA when levels in corn oil-treated rabbits were 10-fold higher than those in rabbits given MGA. Estradiol and progesterone were not different between rabbits given the two treatments. Addition of purified blastokinin to embryo transfer media increased implantation rates in corn oil-treated recipients, but not in recipients pretreated with MGA.
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