Abstract
Summary
Specific activities of tryptic-like inhibitors (TLI) in 27,000g supernatant solutions of mouse uterine homogenates were determined for the following conditions: nonpregnant, pregnant, and delayed implantation. Quantification of inhibitors was achieved by a fluorometric kinetic assay. Inhibitor levels in uteri from Day 4 pregnant and from delayed implantation mice were the same as non-pregnant uterine control values. A significant increase in inhibitor activity (P = 0.05) was found in uteri from Day 6 pregnant mice. This increased activity returned to control levels by Day 12 of pregnancy. Possible functions of TLI in regulating proteolytic activity associated with early development and implantation are discussed.
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