Abstract
Summary
Using Fang-8 cells cultured in serum-free medium, we could clearly demonstrate a stimulatory effect of human prolactin on estrogen biosynthesis without concomitant stimulation of cell growth. The enzymic mechanism involved has not been defined. Human ACTH, rat prolactin, and other human anterior pituitary hormones were ineffective. This finding may bear some relevance to the pathological action of prolactin on the adrenal gland for sex steroidal biosynthesis.
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