Abstract
Summary
Hormonal induction of three hepatic enzymes, phosphoenolpyruvate car-boxykinase, tryptophan oxygenase, and ty-rosine aminotransferase, was significantly inhibited in mice infected with Sindbis virus. Induction of phosphoenolpyruvate carboxy-kinase was suppressed whether it was elicited by overnight fasting or by administration of hydrocortisone. This enzyme responded normally to steroid induction 4 hr after virus administration, but after 6 hr, it was significantly less responsive, The timing of this effect corresponds with the appearance of interferon in the serum of virus-infected mice and mice injected with uvirradiated virus, but results with commercially available interferon make it questionable whether interferon is the factor responsible.
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