Abstract
Summary
In previous studies the ant-helmintic agent, levamisole hydrochloride, has been shown to alter function of mono-cytes and macrophages as well as to increase random locomotion and chemotaxis of neu-trophils. In the present investigation we have extended knowledge about this potentially clinically useful agent. We found that in the optimal range of doses used in prior studies, levamisole produces vacuole formation but does not alter bactericidal activity, oxygen consumption, [l-14C]glucose oxidation, nitroblue tetrazolium reduction, or chemiluminescence of neutrophils from normal subjects. We have also demonstrated that levamisole has no effect on neutrophils from patients with chronic granulomatous disease. The results suggest that the major effects of levamisole on neutrophil function relate to its ability to improve random locomotion and chemotaxis.
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