Abstract
Summary
The drugs actinomycin D, chloramphenicol, cordycepin, and cyclohex-imide were evaluated for their relative effectiveness in blocking zinc binding by liver and mucosa following parenteral zinc. All the drugs, except chloramphenicol, were effective. The majority of the additional zinc bound following parenteral zinc was accounted for as metallothionein (MT) zinc. The inhibition of zinc binding by the drugs used was restricted to that associated with MT. The results collectively indicate that zinc uptake in liver and intestinal cells involves nonmitochondrial transcription and translation of poly(A)-containing RNA. Some of this RNA appears to code for MT.
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