Estrogen-Induced Uterine Hyperemia and Edema Persist during Histamine Receptor Blockade 1

Abstract

Summary

The effect of H₁ and H₂ hista-mine receptor antagonists on estrogen-induced increases in uterine blood volume and uterine water content (edema) was determined. Neither the H₁ or H₂ histamine receptor antagonists nor the combination of both significantly altered either estrogen-induced increases in uterine blood volume or uterine water content. These results suggest that histamine does not play a major role in these physiological responses of the uterus to estrogen.