Abstract
Summary
Rabbits were treated with biweekly intramuscular methotrexate, 2.3 mg/kg, for 1, 2, 6, and 9 months. During these periods, none manifested leukopenia, neutropenia, or monocytopenia of the peripheral blood. After sacrifice, saline la-vages of the lungs revealed progressively decreasing numbers of alveolar macro-phages with time. Bactericidal function tests of the macrophages against S. aureus 502A and P. aeruginosa revealed defective phagocytosis after 6 months of treatment.
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