Abstract
Summary
One hour after insulin administration to healthy, fasting humans, plasma nonesterified fatty acid (NEFA) levels decreased by approximately 40% of the prein-jection value. Contrary to predictions, plasma free tryptophan did not change and plasma bound tryptophan decreased by 12% during the 1 hr after insulin administration. In these subjects, neither bound nor free plasma tryptophan levels are correlated significantly with plasma NEFA levels. These data clearly demonstrate that the levels of free or bound tryptophan in plasma are not regulated by changes in NEFA plasma levels in fasting humans after insulin administration.
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