Abstract
Summary
The present study shows that the detection of the bovine leukemia virus (BLV) in naturally infected cattle or experimentally infected sheep requires the in vitro cultivation of the peripheral blood lymphocytes. This indicates that the infected animals possess a “factor” that inhibits replication of the BLV or expression if its genome. Addition of phytohemagglutinin to the lymphocyte cultures increases the expression of the virus in most, but not all, cases.
This work was supported in part by USPHS Grant 1-Pol-CA-14193-03, Pennsylvania Department of Agriculture Grant ME 4, and USDA Cooperative Agreement 12-14-100-10, 675(45). We also thank Mrs. Betty Thompson for her excellent secretarial help.
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