Abstract
Summary
Cathodal (—) iontophoresis significantly increased the penetration of ara-AMP through adult mouse skin. After penetration into tissues, most of the ara-AMP was rapidly metabolized to ara-A. Even at 24 hr after ara-AMP administration by cathodal (-) iontophoresis, significant amounts of ara-AMP, ara-A, and ara-Hx were determined in the skin acid-soluble fraction. These experiments indicate that iontophoresis is the method of choice for administration of ara-AMP to surface tissues.
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