Abstract
Summary
The relationship between glo-merular filtration rate and tubular glucose reabsorption was examined in rats with experimental glomerulonephritis. Glomerular filtration rates (single kidney) varied from 0.09 to 0.95 ml/min and superficial nephron filtration rates ranged from 4.4 to 38.2 nl/ min. A direct linear relationship between filtration rate and maximal glucose reabsorption rates was observed in individual superficial nephrons as well as in the whole kidney. Changes in peritubular oncotic pressure and extracellular fluid volume modified glucose reabsorptive rates, but the linear relationship between filtration rate and glucose reabsorption persisted. These data support the thesis that glomerulo-tubular balance for glucose is a characteristic feature of renal glucose transport.
The studies referred to in this manuscript were supported by Public Health Service Grant No. T501 HL06008. We are also grateful to Dr. Oliver H.
Lowry and Ms. Margaret Philips for performing the microenzymatic glucose determinations.
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