Abstract
Summary
In cats with gastric fistulas, the histamine H2 receptor agonist N-methyl, 5-methyl histamine gave a higher maximal rate of acid secretion than histamine. Histamine plus a histamine H1 receptor antagonist also gave a higher maximal rate of acid secretion than histamine alone. These findings are compatible with the hypothesis that histamine acts on H1 receptors to inhibit acid secretion.
Supported by a Veterans Administration Senior Medical Investigatorship (M. I. Grossman) and by NIAMDD Grants 08354 and 17328 to CURE (Center for Ulcer Research and Education).
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