Abstract
Summary
Two types of local reactions in canine skin were observed after intradermal injection of chromatographically prepared fractions of human perpheral blood leukocyte lysates. The first reaction peaked within 4 hr after injection, appeared unrelated to antigen, and was characterized by a mild diffuse mononuclear and polymorpho-nuclear infiltrate in the subcutaneous tissue. The second response peaked 30 hr after the injection of antigen onto the site previously prepared with leukocyte lysate. This response appeared to be antigen specific, and was characterized by an early perivascular mononuclear infiltrate followed by a diffuse mononuclear and polymorphonuclear accumulation in the subcutaneous region. Peaks
I and IV most consistently gave positive results.
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