Abstract
Summary
Etiocholanolone was administered to normal subjects and heparinized plasma was collected at varying time intervals from 1.5 to 17 hr afterwards. Control subjects received either no injection or endotoxin, an agent known to increase neu-trophil-releasing activity. Readministration of the autologous plasma to the control subjects who received no injection prior to the plasmaphoresis caused no neutrophilic leu-kocytosis. The plasma obtained after endotoxin and etiocholanolone administration showed neutrophil-releasing activity and the mean activity for pairs of subjects given etiocholanolone was progressively greater through 17 hr after the injection. This study, along with similar studies in human subjects and experimental animals, suggests that the release of neutrophils from the bone marrow is subject to humoral regulation.
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