Effect of Crotalus Atrox Venom on Sodium Transport Across the Frog Skin

Abstract

Summary

The present investigation involving CAV on the ion transport systems in isolated skin has shown that (i) PD and SCC are stimulated in an equal fashion at low concentrations, (ii) R drastically increases at high concentrations, (iii) the mechanism for stimulating SCC is independent of that produced by ADH, (iv) Ca²⁺ abolished any effect on PD or SCC produced by CAV, and (v) active sodium transport is stimulated at low CAV concentrations.

The technical assistance of Ms. E. Colquitt and Mr. R. Nicholson in some of these experiments is gratefully acknowledged.

This investigation was supported by Grant 5 ROI GM-15591 from the National Institutes of Health and a D.S.R. Seed Award (No. 2292 K15).