Abstract
Summary
Studies were initiated in mice to develop a model of cell-mediated immunity to murine cytomegalovirus (MCMV). Immune interferon was produced in response to MCMV antigens in cultures of splenic lymphocytes from mice infected 7, 10, and 14 days previously. However, there was no lymphocyte transformation as measured by antigen-specific enhancement of [ 3 H]thymidine uptake. Lymphocyte transformation in response to phytohemaggluti-nin (PHA) was transiently suppressed in lymphocytes of MCMV-infected mice.
This study was conducted during the senior author's (MWR) sabbatical at the Laboratory of Oral Medicine, NIDR, NIH, Bethesda, Maryland. He wishes to thank Dr. Abner L. Notkins, Chief of the Laboratory of Oral Medicine, for his help with the study and his constructive criticism of the manuscript.
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