Abstract
Summary
The effects of five human body fluids on human fibroblast interferon (MSF-IC) and human leukocyte interferon (WBC-NDV) are reported. After 24 hr at body temperature, WBC-NDV is significantly more stable than MSF-IC in cerebrospinal fluid, saliva, and serum. After 4 hr at 37°, leukocyte interferon is significantly more stable in urine and appears more stable in bile. These findings may be useful in the choice of an exogenous human interferon for clinical studies.
This work was supported in part by Grant No. 05-041-012 from the National Aeronautics and Space Administration and by Public Health Service Grant No. TO1 AI00466 from the National Institute of Allergy and Infectious Diseases.
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