Modification of Cultured Rabbit Cells by Ultraviolet-Inactivated Noncytocidal Shope Fibroma Virus 1

Abstract

Summary

When treated with uv radiation at dosages that abolished infectivity and prevented synthesis of detectable viral DNA or antigens, SFV remained able to modify the cultural behavior of DRK₃ cells and to make them susceptible to unrelated VSV. These cellular modifications were not induced, however, when the input SFV was excessively irradiated. The results suggest that a functional SFV genome is required to alter the DRK₃ cells and that early gene functions of SFV, before synthesis of viral DNA or major antigens, are involved in the modification process.