Abstract
Summary
Geldanamycin, an ansamycin antibiotic having anti-oncornavirus properties, was shown to completely inhibit the induction of measurable endogenous rat leukemia virus by 5-iodo-2′-deoxyuridine in a cell line of Fischer rat embryo cells and to protect the same cells from transformation by the polycyclic hydrocarbon 3-methyl-cholanthrene. Protection was induced at a dosage that was not only non-toxic but slightly stimulatory to cell growth.
The authors wish to thank R. J. Huebner, A. E. Freeman, and E. A. Gregory for their assistance in the preparation of this manuscript.
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