Sequential Response of Pluripotent and Committed Hematopoietic Colony Forming Cells to Rauscher Leukemia Virus 1

Abstract

Summary

The effects of Rauscher leukemia virus injection on the development of response in the CFU-S and CFU-C compartments and on the development of the clinical responses of splenomegaly, total leukocyte, lymphocyte, and granulocyte count have been measured with respect to each other as a function of time. The results indicate an action of Rauscher disease on both the granulocytic and the plu-ripotent stem cell compartments, with the effects on the pluripotent compartment generally preceding or occurring simultaneously with those seen on the committed granulocytic progenitors, the peripheral white blood compartment, and on spleen size. These findings are consistent with the hypothesis that the response of the CFU-S in the disease reflects a direct effect of the virus on that cell, rather than an indirect effect brought about by earlier disturbances occurring among the committed and differentiating stem cells and in the blood-forming organs and the peripheral blood.