Abstract
Summary
To determine whether or not RNA synthesis has a role in uterine glyco-gen deposition due to estrogen stimulation, ovariectomized rats were injected with either dactinomycin, estrogen, or estrogen plus dactinomycin. The antibiotic was administered 30 min prior to estrogen and the rats were killed 2, 4, 6, and 8 hr after hormone treatment. The results show that uterine glycogen is significantly increased at 6 and 8 hr, preceded by an increase in RNA synthesis. The estrogen-induced uterine glycogen is significantly suppressed by the anti-biotic at 6 and 8 hr after the initial hormone treatment. The data indicate that RNA has a major role in the deposition of estrogen-induced uterine glycogen.
Get full access to this article
View all access options for this article.