The Effect of Prostaglandins on the Release of [ 3 H] Dopamine from Superfused Slices of Rat Striatum following Electrical Stimulation 1

Abstract

Summary

It is concluded that prostaglan-dins of the E series, but not F₂α, can decrease the electrically induced release of [³H]dopamine from rat striatal slices. The effect is much less dramatic than that seen on peripheral adrenergic neurons. Prostaglan-dins may play a role in helping to modulate the release of dopamine following nerve stimulation.

The authors wish to thank Ms. Georgia Wahl and Joann Sanders for excellent technical assistance. Thanks are also extended to Dr. John Pike, Upjohn Company, for generous supplies of PGE₁ PGE₂, andPGF₂α