Abstract
Summary
The four cytochalasins studied were found to have quantitative biologic activity at low concentrations, but elicited marked variation in ordering of response when compared in two in vitro systems. All four cytochalasins were teratogenic in vitro. Cytochalasin D was teratogenic at the lowest concentration, while cytochalasin E was the strongest inhibitor of cytokinesis. Since these compounds have been recovered from food and are stable to heat, their biologic activity in man should be studied.
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