Abstract
Summary
Salmonella enteritidis lipopoly-saccharide administered iv to male rats of the Holtzman strain resulted in increased glycogenolysis and decreased gluconeogene-sis in isolated hepatocytes, increased glucose uptake in isolated hemidiaphragms, and enhanced glucose oxidation in epididy-mal fat pads. Endotoxin added in vitro to the identical test systems failed to affect the rates of glycogenolysis, gluconeogenesis, glucose uptake, and glucose oxidation. A mediated as opposed to a direct mechanism of endotoxin action is supported.
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