Abstract
Summary
Immune deposits were observed in the glomerular mesangium of neu-roblastoma-bearing mice which was associated with a mesangial proliferative reaction. Employing specific heterologous antisera and an eluate obtained from neuroblastoma cells, neuroblastoma antigen was identified in kidneys of tumor-bearing mice. Immuno-globulin-containing eluates from kidneys of neuroblastoma-bearing mice were shown to specifically react with viable neuroblastoma cells. These data suggest that the immune deposits noted in kidneys of neuroblastoma-bearing mice are composed of neuroblastoma antigen together with specific antibody and lend further support to the role of tumor-specific immune reactants as causative factors in the pathogenesis of glomerular inflammatory reactions in neuroblastoma-bearing mice.
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