Abstract
Summary
The content of cytochrome P-450 and activities of aniline hydroxylase and glucose-6-phosphatase were determined in the livers of rats fed ethanol and nicotinic acid singly and in combination for 4 weeks. Similar determinations were conducted in livers from rats administered phenobarbital and nicotinic acid alone and in combination for 4 weeks. Both chronic ethanol feeding and phenobarbital administration increased the content of cytochrome P-450 and aniline hydroxylase activity. Glucose-6-phos-phatase activity was elevated by ethanol feeding but not by phenobarbital. Nicotinic acid treatment increased the content of cy-tochrome P-450 and aniline hydroxylation in the ethanol-treated but not in the control or phenobarbital-treated animals. Nicotinic acid did not influence the activity of glucose-6-phosphatase in either the ethanol- or phenobarbital-treated rats. The results of this study are consistent with the existence of a unique cytochrome P-450 which is induced by ethanol feeding, and the induction of this hemoprotein is further enhanced by the concomitant administration of nicotinic acid with ethanol.
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