Abstract
Summary
A decreased chemotactic migration of PMN in vivo and in vitro was observed in PMN from five individuals with P-H anomaly in a family. The decreased chemotactic migration was more pronounced when the PMN were made to migrate through a filter paper with small pore size. The decreased migration may be in part due to the mechanical hindrance of the large unsegmented nucleus to the migration of the cells.
We thank Dr. Elliot F. Ellis, Professor and Chairman, Department of Pediatrics, for his support and guidance throughout this investigation.
A portion of this report was presented in the annual meeting of the Federation of the American Society for Experimental Biology on April 13, 1976.
This work was supported in part by Grants HL-19628-01 and BRS-342.23.148 from the NIH.
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